Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, Korea. Department of Internal Medicine, Naju National Hospital, Naju, Korea. Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Seoul, Korea. Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, Korea bkkoo@snu.ac.kr. Institute on Aging, Seoul National University, Seoul, Korea. Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea. Division of Cardiology, Dietrich Bonhoeffer Hospital, Academic Teaching Hospital of University of Greifswald, Greifswald, Germany. Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea. Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea. Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. Department of Cardiology, Tokyo Medical University, Tokyo, Japan. Kokura Memorial Hospital, Kitakyuku, Japan. Department of Cardiology, Gifu Heart Center, Gifu, Japan. Department of Cardiology, Aichi Medical University, Nagakute, Japan. Wakayama Medical University, Wakayama, Japan.